Mentha × piperita · PhytoNexus

01 Identity and provenance

Accepted binomial: Mentha × piperita
Common names: Peppermint
Family (APG IV): Lamiaceae
Part used: Leaf
Verification tier: Tier 2 · Verified Clinical columns reviewed and a source is on record.
Reviewer note (2026 audit): Reference not supplied - claim unverified against primary literature.

02 Constituent chemistry

Chemical class	Marker compound	Synthetic analogue in use
Menthol	Menthone Leaf	Dicyclomine

The analogue column is what makes the interaction reasoning tractable: where a constituent has a marketed structural counterpart, the counterpart's interaction profile is the starting hypothesis for the plant.

Looking up structures and physicochemical properties from PubChem…

03 Stated application

Reported activity: Digestive aid
Marketed in: Capsule , Syrup
Reported adverse effects: Acid reflux

04 Interaction matrix

Source column, verbatim: Antacids
Normalised onto 1 canonical drug class below.

Curated from the reviewed source

Drug class	Severity	Mechanism type	Provenance	Expected effect
Antacids, PPIs and H2 blockers Gastrointestinal	2Moderate	PK-absorption	curated B	Reduced or erratic absorption of alkaloids; heartburn and reflux from pre…	why ▾
Class mechanism. Gastric pH elevation alters the dissolution and ionisation of alkaloidal and enteric-coated botanical products; menthol- and peppermint-oil products lose their enteric protection at high pH and can be released prematurely. Expected Reduced or erratic absorption of alkaloids; heartburn and reflux from premature release of volatile-oil preparations. Management Separate administration by 2 hours. Avoid non-enteric peppermint oil in reflux disease. Onset unspecified Evidence B - reviewed clinical column, source pending Matched on “antacids” Find evidence for this pair Map this mechanism

05 Hazard register

The audit recorded no hazard beyond the interaction profile. The controlled-vocabulary field reads not assessed, which means the assessment has not been done rather than that it came back clear.

06 Confusable material

These entries could be mistaken for this one in trade, in the herbarium, or in a prescription. Powdered material is often indistinguishable, so the check is macroscopic, microscopic and chromatographic rather than nominal.

Mentha arvensis Japanese Mint	Lamiaceae	Same genus (Mentha)
Mentha spicata Spearmint	Lamiaceae	Same genus (Mentha)

07 Mechanism map

Chemistry sorts to the left, pharmacology to the right. Dashed edges are predicted. Drag nodes, scroll to zoom, export at 3× for a figure.

species

chemical class

marker compound

drug class

expected effect

hazard

08 Open literature

Abstract-scoped query built from this binomial, its common names and its marker compounds, run live against Europe PMC, PubMed and OpenAlex, then ranked locally against an evidence hierarchy.

Checking openFDA spontaneous reports…

09 Isomechanistic neighbours

Species whose interaction profile overlaps this one, ranked by shared severity weight rather than by count — a shared contraindication counts for more than a shared minor signal. Practical use: these are the plants you should not stack with this one, because the mechanisms summate.

Species	Family	Shared classes	Jaccard
Mentha spicata Spearmint	Lamiaceae	1	1.00
Holarrhena pubescens Kurchi	Apocynaceae	1	0.50
Sida cordifolia Bala	Malvaceae	1	0.50
Solanum virginianum Kantakari	Solanaceae	1	0.50
Tylophora indica Antamul	Apocynaceae	1	0.50
Carica papaya Papaya	Caricaceae	1	0.50

10 References and notes

No citation is on record for this entry. That is itself the finding: the audit flagged it, and it is why the entry does not carry an A evidence grade.

Curator notes

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