Rhodiola rosea · PhytoNexus

01 Identity and provenance

Accepted binomial: Rhodiola rosea
Common names: Rhodiola
Family (APG IV): Crassulaceae
Part used: Rhizome
Verification tier: Tier 2 · Unverified Clinical columns are populated but no primary reference was supplied. Treat the interaction list as a hypothesis to be checked against literature.

02 Constituent chemistry

Chemical class	Marker compound	Synthetic analogue in use
Rosavin	salidroside, Rosavin Rhizome	Modafinil

The analogue column is what makes the interaction reasoning tractable: where a constituent has a marketed structural counterpart, the counterpart's interaction profile is the starting hypothesis for the plant.

Looking up structures and physicochemical properties from PubChem…

03 Stated application

Reported activity: stress reduction, fatigue, depression
Marketed in: Himalaya wellness - Tablets
Reported adverse effects: Insomnia, dizziness, dry mouth

04 Interaction matrix

Source column, verbatim: Anti depressant, Anti hypertensive, CNS stimulant
Normalised onto 3 canonical drug classes below.

Curated from the reviewed source

Drug class	Severity	Mechanism type	Provenance	Expected effect
Antidepressants (SSRI, SNRI, TCA) CNS	3Major	PD-additive serotonergic + PK-CYP2D6	curated A	Serotonin syndrome (agitation, clonus, hyperthermia, autonomic instabilit…	why ▾
Class mechanism. Hypericin- and hyperforin-type constituents inhibit monoamine reuptake and induce CYP3A4/2C19 and P-glycoprotein; others inhibit CYP2D6, raising tricyclic and SSRI concentrations. Expected Serotonin syndrome (agitation, clonus, hyperthermia, autonomic instability) or loss of antidepressant effect on withdrawal of an inducer. Management Screen for serotonergic burden before adding. Taper rather than stop abruptly. Consider therapeutic drug monitoring for tricyclics. Onset rapid Evidence A - human data with a cited source Matched on “anti depressant” Find evidence for this pair Map this mechanism
CNS stimulants and sympathomimetics CNS	3Major	PD-additive	curated A	Tachycardia, hypertension, arrhythmia, insomnia, anxiety, stroke and myoc…	why ▾
Class mechanism. Ephedrine, pseudoephedrine, caffeine, synephrine and cathine-type constituents add to prescribed stimulant and decongestant sympathomimetic drive. Expected Tachycardia, hypertension, arrhythmia, insomnia, anxiety, stroke and myocardial infarction in susceptible people. Management Avoid in cardiovascular disease, hyperthyroidism and pregnancy. Ask about weight-loss and sports supplements by brand. Onset rapid Evidence A - human data with a cited source Matched on “cns stimulant” Find evidence for this pair Map this mechanism
Antihypertensives Cardiovascular	2Moderate	PD-additive	curated A	Orthostatic hypotension, dizziness, syncope and falls; or loss of blood-p…	why ▾
Class mechanism. Vasodilator, diuretic, ACE-inhibitory and calcium-antagonist activity in botanical extracts adds to prescribed blood-pressure lowering. A minority (ephedrine-, glycyrrhizin- and caffeine-bearing) act in the opposite direction and antagonise control. Expected Orthostatic hypotension, dizziness, syncope and falls; or loss of blood-pressure control with pressor botanicals. Management Home BP log for 2 weeks after any change. Warn about postural symptoms; review in the elderly and in those on multiple agents. Onset rapid Evidence A - human data with a cited source Matched on “anti hypertensive” Find evidence for this pair Map this mechanism

05 Hazard register

The audit recorded no hazard beyond the interaction profile. The controlled-vocabulary field reads not assessed, which means the assessment has not been done rather than that it came back clear.

06 Confusable material

No same-genus or shared-common-name entry in the corpus.

07 Mechanism map

Chemistry sorts to the left, pharmacology to the right. Dashed edges are predicted. Drag nodes, scroll to zoom, export at 3× for a figure.

species

chemical class

marker compound

drug class

expected effect

hazard

08 Open literature

Abstract-scoped query built from this binomial, its common names and its marker compounds, run live against Europe PMC, PubMed and OpenAlex, then ranked locally against an evidence hierarchy.

Checking openFDA spontaneous reports…

09 Isomechanistic neighbours

Species whose interaction profile overlaps this one, ranked by shared severity weight rather than by count — a shared contraindication counts for more than a shared minor signal. Practical use: these are the plants you should not stack with this one, because the mechanisms summate.

Species	Family	Shared classes	Jaccard
Strychnos nux-vomica Nux Vomica	Loganiaceae	3	0.33
Ephedra sinica Ephedra	Ephedraceae	3	0.38
Peganum harmala Syrian Rue	Nitrariaceae	3	0.38
Ephedra gerardiana Himalayan Ephedra	Ephedraceae	3	0.30
Rauvolfia serpentina Sarpagandha	Apocynaceae	2	0.29
Catharanthus roseus Periwinkle	Apocynaceae	2	0.29

10 References and notes

Source column: WHO Monographs; PubMed; Rhodiola rosea Review (Phytomedicine)

WHO Monographs

Official monograph manual

Rhodiola rosea Review (Phytomedicine)

Narrative review manual

PubMed

manual

BibTeX for all 3 records

@article{anon,
  title = {WHO Monographs},
}

@article{anon,
  title = {Rhodiola rosea Review (Phytomedicine)},
}

@article{anon,
  title = {PubMed},
}

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