Six public APIs, no keys and no paywall. Queries are scoped to title and abstract rather than full text, because a full-text hit on Curcuma in a reference list is not evidence of anything. Everything retrieved is then passed through an interaction-vocabulary gate: a paper is admitted only if it actually describes an interaction, not merely because it names a plant and a drug in the same abstract. What survives is ranked against an eight-level evidence hierarchy, so a randomised trial outranks a review that cites it.
Botanical mu-agonists and CNS depressants add to opioid respiratory and sedative effect; CYP2D6 and CYP3A4 modulation alters the conversion of codeine and tramadol to active metabolites.
Expected clinically: Respiratory depression, over-sedation, constipation, ileus; unpredictable analgesia in CYP2D6 poor or ultrarapid metabolisers.