Six public APIs, no keys and no paywall. Queries are scoped to title and abstract rather than full text, because a full-text hit on Curcuma in a reference list is not evidence of anything. Everything retrieved is then passed through an interaction-vocabulary gate: a paper is admitted only if it actually describes an interaction, not merely because it names a plant and a drug in the same abstract. What survives is ranked against an eight-level evidence hierarchy, so a randomised trial outranks a review that cites it.
Physostigmine-, galantamine- and arecoline-type constituents inhibit acetylcholinesterase or agonise muscarinic receptors, adding to donepezil, rivastigmine, neostigmine or pyridostigmine.
Expected clinically: Cholinergic crisis: bradycardia, bronchorrhoea, bronchospasm, miosis, seizures, weakness that mimics myasthenic crisis.