Six public APIs, no keys and no paywall. Queries are scoped to title and abstract rather than full text, because a full-text hit on Curcuma in a reference list is not evidence of anything. Everything retrieved is then passed through an interaction-vocabulary gate: a paper is admitted only if it actually describes an interaction, not merely because it names a plant and a drug in the same abstract. What survives is ranked against an eight-level evidence hierarchy, so a randomised trial outranks a review that cites it.
Anthraquinone and mucilage botanicals add to stimulant and bulk laxative action; tannin-rich astringents oppose it.
Expected clinically: Cramping, diarrhoea, electrolyte loss, melanosis coli with chronic anthraquinone use; or constipation and obstruction risk with astringents plus inadequate fluid.