Six public APIs, no keys and no paywall. Queries are scoped to title and abstract rather than full text, because a full-text hit on Curcuma in a reference list is not evidence of anything. Everything retrieved is then passed through an interaction-vocabulary gate: a paper is admitted only if it actually describes an interaction, not merely because it names a plant and a drug in the same abstract. What survives is ranked against an eight-level evidence hierarchy, so a randomised trial outranks a review that cites it.
Sesquiterpene lactones, urushiol-type catechols and protein allergens cause type I and type IV reactions with well-documented cross-reactivity across the Asteraceae and Apiaceae.
Expected clinically: Urticaria, angio-oedema, allergic contact dermatitis, anaphylaxis; cross-reaction with related species.