60 nodes · 80 edges · Piper methysticum · Senna alexandrina · Camellia sinensis · Hypericum perforatum
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Drug classes reached by more than one of the selected botanicals. This is where a polyherbal regimen stops being a list of separate interactions and becomes additive pressure on a single mechanism — the reason the composite view exists.
| Drug class | Mechanism | Hits | Curated | Peak | Contributed by |
|---|---|---|---|---|---|
| Narrow-therapeutic-index CYP3A4 substrates | PK-CYP3A4 | 4 | 1 | 4Contraindicated | Camellia sinensis · Hypericum perforatum · Piper methysticum · Senna alexandrina |
| Cytotoxic and targeted anticancer drugs | PK-CYP3A4/UGT + PD-antagonistic | 3 | 1 | 4Contraindicated | Camellia sinensis · Hypericum perforatum · Senna alexandrina |
| Antiarrhythmics | PD-additive + electrolyte-mediated | 2 | 1 | 4Contraindicated | Camellia sinensis · Senna alexandrina |
| Antidepressants (SSRI, SNRI, TCA) | PD-additive serotonergic + PK-CYP2D6 | 2 | 2 | 4Contraindicated | Hypericum perforatum · Piper methysticum |
| Hepatotoxic drugs | Organ-toxicity additive | 2 | 1 | 4Contraindicated | Hypericum perforatum · Piper methysticum |
| Antiplatelet agents | PD-additive | 3 | 1 | 3Major | Camellia sinensis · Hypericum perforatum · Senna alexandrina |
| Statins and lipid-lowering drugs | PK-CYP3A4/OATP | 3 | 0 | 2Moderate | Camellia sinensis · Hypericum perforatum · Senna alexandrina |
| Antacids, PPIs and H2 blockers | PK-absorption | 2 | 0 | 2Moderate | Piper methysticum · Senna alexandrina |
| Iron, calcium and mineral supplements | PK-chelation | 2 | 1 | 2Moderate | Camellia sinensis · Senna alexandrina |