Eclipta prostrata · PhytoNexus

01 Identity and provenance

Accepted binomial: Eclipta prostrata
Common names: Bhringraj
Family (APG IV): Asteraceae
Part used: Whole plant
Verification tier: Tier 2 · Unverified Clinical columns are populated but no primary reference was supplied. Treat the interaction list as a hypothesis to be checked against literature.

02 Constituent chemistry

Chemical class	Marker compound	Synthetic analogue in use
wedelolactone, ecliptine	wedelolactone Whole plant	minoxidil

The analogue column is what makes the interaction reasoning tractable: where a constituent has a marketed structural counterpart, the counterpart's interaction profile is the starting hypothesis for the plant.

Looking up structures and physicochemical properties from PubChem…

03 Stated application

Reported activity: hair growth, liver protection, wound healing
Marketed in: Dabur - Bhringraj hair oil, Indulekha - Bringha hair oil
Reported adverse effects: skin irritation, nausea, diarrhea

04 Interaction matrix

Source column, verbatim: anti coagulant, anti diabetic, hepatotoxic drugs
Normalised onto 3 canonical drug classes below.

Curated from the reviewed source

Drug class	Severity	Mechanism type	Provenance	Expected effect
Anticoagulants (vitamin-K antagonists, DOACs) Haemostasis	3Major	PD-additive + PK-CYP2C9	curated A	INR destabilisation in either direction; ecchymosis, epistaxis, gum bleed…	why ▾
Class mechanism. Coumarin-, salicylate- and coumestan-bearing botanicals add to vitamin-K-antagonist effect; several also compete for CYP2C9 and CYP3A4, raising S-warfarin exposure. Botanicals rich in vitamin K1 act in the opposite direction and blunt anticoagulation. Expected INR destabilisation in either direction; ecchymosis, epistaxis, gum bleeding, GI or intracranial haemorrhage. Management Do not start or stop the botanical without INR cover. Check INR at 3-5 days and again at 2 weeks. Document the product, batch and dose in the anticoagulation record. Onset rapid Evidence A - human data with a cited source Matched on “anti coagulant” Find evidence for this pair Map this mechanism
Antidiabetic drugs (insulin, sulfonylureas, biguanides, GLP-1, SGLT2) Endocrine	3Major	PD-additive	curated A	Symptomatic hypoglycaemia, sweating, tremor, confusion; severe events rep…	why ▾
Class mechanism. Hypoglycaemic botanicals act through insulin secretagogue, insulin-sensitising, alpha-glucosidase-inhibiting or glucose-transport routes. Added to a titrated pharmacological regimen the effects summate rather than plateau. Expected Symptomatic hypoglycaemia, sweating, tremor, confusion; severe events reported with insulin and sulfonylureas. Management Increase self-monitoring frequency for 2 weeks after starting or stopping. Anticipate a downward dose adjustment of insulin or sulfonylurea. Onset rapid Evidence A - human data with a cited source Matched on “anti diabetic” Find evidence for this pair Map this mechanism
Hepatotoxic drugs Organ toxicity	3Major	Organ-toxicity additive	curated A	Transaminase elevation, cholestasis, sinusoidal obstruction syndrome, acu…	why ▾
Class mechanism. Pyrrolizidine alkaloids, high-dose anthraquinones, kava constituents and germander-type diterpenes cause hepatocellular or sinusoidal injury that adds to the risk from paracetamol, isoniazid, methotrexate, azoles and statins. Expected Transaminase elevation, cholestasis, sinusoidal obstruction syndrome, acute liver failure. Management Baseline and 4-weekly ALT and bilirubin. Stop the botanical at any transaminase rise above three times the upper reference limit. Onset unspecified Evidence A - human data with a cited source Matched on “hepatotoxic drugs” Find evidence for this pair Map this mechanism

05 Hazard register

The audit recorded no hazard beyond the interaction profile. The controlled-vocabulary field reads not assessed, which means the assessment has not been done rather than that it came back clear.

06 Confusable material

No same-genus or shared-common-name entry in the corpus.

07 Mechanism map

Chemistry sorts to the left, pharmacology to the right. Dashed edges are predicted. Drag nodes, scroll to zoom, export at 3× for a figure.

species

chemical class

marker compound

drug class

expected effect

hazard

08 Open literature

Abstract-scoped query built from this binomial, its common names and its marker compounds, run live against Europe PMC, PubMed and OpenAlex, then ranked locally against an evidence hierarchy.

Checking openFDA spontaneous reports…

09 Isomechanistic neighbours

Species whose interaction profile overlaps this one, ranked by shared severity weight rather than by count — a shared contraindication counts for more than a shared minor signal. Practical use: these are the plants you should not stack with this one, because the mechanisms summate.

Species	Family	Shared classes	Jaccard
Ocimum tenuiflorum Tulsi	Lamiaceae	3	0.38
Syzygium aromaticum Clove	Myrtaceae	3	0.60
Allium sativum Garlic	Amaryllidaceae	2	0.40
Commiphora wightii Guggul	Burseraceae	2	0.50
Cinnamomum verum Cinnamon	Lauraceae	2	0.50
Trachyspermum ammi Ajwain	Apiaceae	2	0.40

10 References and notes

Source column: Ayurvedic Pharmacopoeia of India; PubMed

Ayurvedic Pharmacopoeia of India

Official monograph manual

PubMed

manual

BibTeX for all 2 records

@article{anon,
  title = {Ayurvedic Pharmacopoeia of India},
}

@article{anon,
  title = {PubMed},
}

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