01 Identity and provenance
- Accepted binomial
- Boerhavia diffusa
- Common names
- Punarnava
- Family (APG IV)
- Nyctaginaceae
- Part used
- Root
- Verification tier
- Tier 2 · Verified Clinical columns reviewed and a source is on record.
- Reviewer note (2026 audit)
- Reference not supplied - claim unverified against primary literature.
02 Constituent chemistry
| Chemical class | Marker compound | Synthetic analogue in use |
|---|---|---|
| punarnavine | punarnavine
Root
|
Furosemide |
The analogue column is what makes the interaction reasoning tractable: where a constituent has a marketed structural counterpart, the counterpart's interaction profile is the starting hypothesis for the plant.
03 Stated application
- Reported activity
- Diuretic
- Marketed in
- Punarnava Churna
- Reported adverse effects
- Frequent urination
04 Interaction matrix
Source column, verbatim: Diuretics
Normalised onto 1 canonical drug class below.
Curated from the reviewed source
| Drug class | Severity | Mechanism type | Provenance | Expected effect | |
|---|---|---|---|---|---|
|
Diuretics
Renal
|
3Major | PD-additive + electrolyte-mediated | curated B | Hypokalaemia, hyponatraemia, dehydration, muscle weakness, cramps, arrhyt… | why ▾ |
Class mechanism. Aquaretic and saluretic botanicals add to renal potassium and sodium loss. Anthraquinone laxatives compound this through colonic potassium loss, and glycyrrhizin causes mineralocorticoid-like retention of sodium with kaliuresis.
| |||||
05 Hazard register
The audit recorded no hazard beyond the interaction profile. The controlled-vocabulary field reads not assessed, which means the assessment has not been done rather than that it came back clear.
06 Confusable material
No same-genus or shared-common-name entry in the corpus.
07 Mechanism map
Chemistry sorts to the left, pharmacology to the right. Dashed edges are predicted. Drag nodes, scroll to zoom, export at 3× for a figure.
08 Open literature
Abstract-scoped query built from this binomial, its common names and its marker compounds, run live against Europe PMC, PubMed and OpenAlex, then ranked locally against an evidence hierarchy.
09 Isomechanistic neighbours
Species whose interaction profile overlaps this one, ranked by shared severity weight rather than by count — a shared contraindication counts for more than a shared minor signal. Practical use: these are the plants you should not stack with this one, because the mechanisms summate.
| Species | Family | Shared classes | Weight | Jaccard |
|---|---|---|---|---|
| Digitalis purpurea
Foxglove |
Plantaginaceae | 1 | 0.33 | |
| Digitalis lanata
Woolly Foxglove (Grecian Foxglove) |
Plantaginaceae | 1 | 0.33 | |
| Cissampelos pareira
Patha |
Menispermaceae | 1 | 1.00 | |
| Nerium oleander
Kaner (Oleander) |
Apocynaceae | 1 | 0.33 | |
| Cascabela thevetia
Yellow Oleander |
Apocynaceae | 1 | 0.33 | |
| Urginea indica
Indian Squill |
Asparagaceae | 1 | 0.33 |
10 References and notes
No citation is on record for this entry. That is itself the finding: the audit flagged it, and it is why the entry does not carry an A evidence grade.
Curator notes
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