01 Identity and provenance
- Accepted binomial
- Andrographis paniculata
- Common names
- Kalmegh
- Family (APG IV)
- Acanthaceae
- Part used
- Whole plant
- Verification tier
- Tier 2 · Verified Clinical columns reviewed and a source is on record.
- Reviewer note (2026 audit)
- Reference not supplied - claim unverified against primary literature.
02 Constituent chemistry
| Chemical class | Marker compound | Synthetic analogue in use |
|---|---|---|
| Andrographolide | Andrographolide
Whole plant
|
Paracetamol |
The analogue column is what makes the interaction reasoning tractable: where a constituent has a marketed structural counterpart, the counterpart's interaction profile is the starting hypothesis for the plant.
03 Stated application
- Reported activity
- Hepatoprotective
- Marketed in
- Kalmegh tablets
- Reported adverse effects
- Loss of appetite
04 Interaction matrix
Source column, verbatim: Antidiabetic drugs
Normalised onto 1 canonical drug class below.
Curated from the reviewed source
| Drug class | Severity | Mechanism type | Provenance | Expected effect | |
|---|---|---|---|---|---|
|
Antidiabetic drugs (insulin, sulfonylureas, biguanides, GLP-1, SGLT2)
Endocrine
|
3Major | PD-additive | curated B | Symptomatic hypoglycaemia, sweating, tremor, confusion; severe events rep… | why ▾ |
Class mechanism. Hypoglycaemic botanicals act through insulin secretagogue, insulin-sensitising, alpha-glucosidase-inhibiting or glucose-transport routes. Added to a titrated pharmacological regimen the effects summate rather than plateau.
| |||||
05 Hazard register
The audit recorded no hazard beyond the interaction profile. The controlled-vocabulary field reads not assessed, which means the assessment has not been done rather than that it came back clear.
06 Confusable material
No same-genus or shared-common-name entry in the corpus.
07 Mechanism map
Chemistry sorts to the left, pharmacology to the right. Dashed edges are predicted. Drag nodes, scroll to zoom, export at 3× for a figure.
08 Open literature
Abstract-scoped query built from this binomial, its common names and its marker compounds, run live against Europe PMC, PubMed and OpenAlex, then ranked locally against an evidence hierarchy.
09 Isomechanistic neighbours
Species whose interaction profile overlaps this one, ranked by shared severity weight rather than by count — a shared contraindication counts for more than a shared minor signal. Practical use: these are the plants you should not stack with this one, because the mechanisms summate.
| Species | Family | Shared classes | Weight | Jaccard |
|---|---|---|---|---|
| Anethum graveolens
Dill |
Apiaceae | 1 | 1.00 | |
| Swertia chirayita
Chirata |
Gentianaceae | 1 | 0.50 | |
| Garcinia cambogia
Garcinia |
Clusiaceae | 1 | 1.00 | |
| Boswellia serrata
Boswellia |
Burseraceae | 1 | 1.00 | |
| Pterocarpus santalinus
Red Sandalwood |
Fabaceae | 1 | 1.00 | |
| Rosa canina
Rosehip |
Rosaceae | 1 | 0.50 |
10 References and notes
No citation is on record for this entry. That is itself the finding: the audit flagged it, and it is why the entry does not carry an A evidence grade.
Curator notes
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